ABSTRACT
To explore the medication rule of Chinese materia medica (CMM) in the treatment of pulmonary fibrosis, and provide reference for the prevention and treatment of pulmonary fibrosis in the novel coronavirus pneumonia. Using Excel 2013 and SPSS Statistics 23.0, the literatures with the theme of “pulmonary fibrosis” that met the screening criteria were searched, and the association rule analysis was carried out. Frequency analysis showed that the occurrence frequency of Astragali Radix (148, 45.82%), Glycyrrhizae Radix et Rhizoma (124, 38.39%) and Salviae Miltiorrhizae Radix et Rhizoma (102, 31.58%) was the highest in the clinical treatment literature. In the statistics of nature and flavor, warm (10 times, 50.00%) and neutral (six times, 30.00%) were the most common. The highest frequency of meridian tropism was found in the spleen (11 times, 25.58%), lung (10 times, 23.26%) and sweet (11 times, 36.67%). In the analysis of association rules, six groups of TCM combinations with high frequency correlation strength were obtained. The high frequency and high correlation CMM combinations obtained from this data analysis were mainly effective in strengthening the spleen and invigorating qi, and warming the spleen and lung, which can be used to prevent the early patients from developing to the critical stage and prevent the patients from reinfection due to low immunity in the convalescence stage.
ABSTRACT
Recently, the epidemic of novel coronavirus pneumonia (COVID-19) in China and other countries in the world is serious. There are at present no effective treatments for COVID-19. The safety and effectiveness of western anti-coronavirus drugs are under investigation. In many places in China, traditional Chinese medicine (TCM) has been used to treat COVID-19 with a high clinical cure rate. The treatment economics of TCM is good. The immune-regulating and antiviral TCM can enhance human immunity and exert an antiviral effect. They have been widely used in the anti-COVID-19 treatment. We consulted the database of CNKI, Wanfang, VIP and PubMed for screening the immune-regulating and antiviral TCMs (Glycyrrhizae Radix et Rhizoma, Pogostemonis Herba, Lonicerae Japonicae Flos, Scutellariae Radix, Forsythiae Fructus, Magnoliae Officinalis Cortex, Bupleuri Radix, Isatidis Radix, Rhei Radix et Rhizoma, Astragali Radix, and Houttuyniae Herba). This article summarizes the physicochemical and pharmacokinetic characteristics, and the clinical application of the effective components of immune-regulating and antiviral TCM in the prescriptions and Chinese patent medicines, in order to provide a better reference for the clinical application of TCM.
ABSTRACT
The development of Chinese materia medica (CMM) has risen to the level of national strategy. Under the new situation that the pharmaceutical industry implements the "Made in China 2025" strategy, quality control of the production process of CMM is one of the key areas in which the CMM industry needs to accelerate its breakthrough. The key common issues in process design, analysis and detection, process modeling, and manufacturing equipment and other aspects in the field of quality control of CMM production processes was analyzed in the paper. The progress in the three aspects of process understanding, real-time analysis method development and process control strategy establishment in the quality control system of CMM production process was reviewed. Combined with the author's corporate research practices, this paper introduces the application progress of key technologies such as quality by design (QbD), process analytical technology (PAT), experimental design (DOE), and multivariate statistical analysis in the above three research directions, and analyzes the difficulties problems in practical industrial application. The application prospect is prospected. The purpose of this article is to provide reference for CMM enterprises to apply and improve the quality control technology in the production process.
ABSTRACT
The identification of Chinese materia medica (CMM) characters, an important part of the quality standard of CMM, is one of the overall quality indicators of CMM. It is an old technical problem facing the inheritance and innovation of experience identification of Chinese medicine industry. However, the regulation of CMM characters recorded in the Chinese Pharmacopoeia and other local drug standards and processing specifications are still staying at words description, relying on human sensory judgment, so the operability needs to be improved. This paper puts forward the proposal to establish a quality standard for CMM identification for the use of reference herbal pieces and Chinese medicinal herb for the identification of characters, and provides basic support for the objective digital research of CMM characters identification, which is helpful to improve the quality evaluation of CMM.
ABSTRACT
Q-marker of Chinese materia medica (CMM) is a latest proposed core concept of CMM quality evaluation and quality control. A wide range of relevant researches on the Q-marker have been carried out by science and technology workers since the concept was put forward. However, to date, most studies are still limited to Q-marker studies of single herbs and pieces and cannot fully reflect all the elements of the concept of Q-marker. In this paper, the scientific connotation of five elements and the principles, ideas and approaches for the discovery and determination of CMM Q-marker were systemically discussed from the perspectives of quality transmissibility and traceability, ingredient specificity, component validity, component measurability, and formula compatibility environment. Moreover, research approaches of Q-marker of CMM formula based on “five principles” were proposed. The examples of representative researches provide a systematic research idea and reference for the research and discovery of CMM Q-marker.
ABSTRACT
Angiogenesis involves the occurrence and development of serious diseases such as cardiovascular and cerebrovascular diseases and malignant tumors. Promoting or inhibiting angiogenesis is considered to be a key factor in controlling the progression of the disease. Chinese materia medica (CMM) has become a research hotspot because of its good clinical therapeutic effect and significant intervention on angiogenesis. The zebrafish model as an ideal animal model also provides a good experimental basis for the study of angiogenesis. CMM monomers, extracts, prescriptions and Chinese patent medicine, and other forms of intervention were selected as the research object. Based on zebrafish animal model experiments, we summarize domestic and foreign relevant research and review the research progress of the effect of CMM on angiogenesis in zebrafish, aiming to provide reference for further development and application of zebrafish as a model and further study of CMM intervention in angiogenesis.
ABSTRACT
Study on the pharmacodynamic material basis of Chinese materia medica (CMM) is the key and difficult points of CMM research due to its complicated components and synergistic effect of multiple pathways and multiple targets in pharmacological action. Currently, research ideas and research methods of the pharmacodynamic material basis of CMM are being constantly innovated. In this review, research ideas and progress on screening and identification of pharmacodynamic substance of CMM were summarized. It suggested that the research model of interdisciplinarity, multi-dimensional screening and evaluation should be established, in order to provide references for further and comprehensively revealing the mechanism of action of CMM and the law of compatibility, and establishing quality evaluation system of CMM.
ABSTRACT
Objective To assess the effectiveness of Chinese materia medica (CMM) as adjuvant therapy of antibacterial for pediatric mesenteric lymphadenitis.Methods Retrieved RCT research of CMM as adjuvant therapy of antibacterial for pediatric mesenteric lymphadenitis from CNKI,Wanfang,VIP,PubMed,and Medline database from 1980 to 2016.Literatures were selected according to the inclusion and exclusion crteria,Jadad scores method was used to evaluate the literatures and meta-analysis was performed by RevMan 5.3.Results A total of 34 randomized controlled trials were included.Meta-analysis showed that the trial group was superior to the control group in terms of efficiency,cure rate,remission time of main symptoms,mesenteric lymph node recovery,and recurrence rate,there was statistical difference.Conclusions CMM as adjuvant therapy of antibacterial for pediatric mesenteric lymphadenitis is more effective than the use of antibacterial alone.
ABSTRACT
In this study, medicine manufacturing technology innovation efficiency measures analyze and improve the competitiveness of the industry. The innovation rate of Chinese materia medica (CMM) manufacturing technology in Jiangsu Province (2009-2014) was analyzed according to statical panel data and dynamic given years by data envelopment analysis (DEA) and Malmquist index method. Chinese manufacturing innovation has overall higher efficiency of Jiangsu province, and Chinese medicine efficiency of technological innovation in manufacturing is higher than that of Chinese herbal pieces manufacturing. The proprietary manufacturing technology innovation inputs and outputs on the overall operation is relatively active; During six years, medicine manufacturing technology innovation efficiency in Jiangsu province has a certain magnitude of negative growth (-3.1%), efficiency of technological innovation presents zigzag upward trend; Medicine manufacturing technology innovation efficiency, Jiangsu Province, there are regional differences among cities. Through increased investment and innovation to achieve efficient use of resources, optimize the industrial structure and improve relevant policies, we can effectively improve the efficiency of technological innovation of Chinese manufacturing.
ABSTRACT
Eight financial indicators of 16 listed companies of Chinese materia medica (CMM) in 2014 were selected by factor analysis method. A comprehensive growth evaluation system was established, so as to make an empirical research on growth evaluation among 16 CMM listed companies. Results show: Sixteen CMM listed companies' scale and growth differences among the companies is significant, and overall growth performance should be improved. On the aspect of scale ability, profitability, and growth ability, Jilin Aodong Medicine Industry Group Co., Ltd. (score 29.492), Guangzhou Baiyun Mountain Pharmaceutical Co., Ltd (Baiyun Mountain) (score 31.809), Dongbao Pharmaceutical Co., Ltd. (score 42.110) separately ranked first. The best growth is Baiyun Mountain (score 31.089), and the worst is Taiji Group Co., Ltd. (score -7.053). Some suggestions should be put forward: Increase research and investment, enhance innovation, improve the management ability of CMM listed companies; Strengthen the integration of advantageous resources and optimize the structure of products, realizing the scaled and sustained development of CMM listed companies; Establish brand awareness and strengthen internal management, so as to enhance the market competitiveness of CMM listed companies, etc.
ABSTRACT
Revaluation of syndrome therapeutic effect of post-marketing Chinese materia medica (CMM) is a necessary complement to pre-ipo syndrome therapeutic effect evaluation. With the transition of research stage and research target, the evaluation method needs a breakthrough and innovation. So considering the academic characteristics of syndrome theory of traditional Chinese medicine (TCM), concerning the key link in the process of design and implementation in syndrome curative effect evaluation, and analyzing the common problems in syndrome curative effect evaluation are the urgent needs to change the current syndrome curative effect evaluation. Through analyzing the type and level of efficacy evaluation in TCM and interpreting the current situation and demand of syndrome therapeutic effect revaluation for post-marketing CMM, here this paper tried to put forward the research of revaluation of syndrome therapeutic effect for post-marketing CMM, which involved in research of symptoms unit, expression of specification symptoms, and symptoms of selection and optimization. Then drawing lessons from study design with effective registration and combining the concept of causality research could list some inspiration for how to establish the syndrome therapeutic effect revaluation for post-marketing CMM.
ABSTRACT
The toxicity of Chinese materia medica (CMM) is one of cores of the property theory of CMM. From the perspective of history, the literature source of the understanding on CMM toxicity was traced; The traditional and contemporary understanding about the meaning and classification of CMM toxicity was compared and analyzed; The ideas on CMM toxicity with the feature of tradition, experience, objectivity, the integrity of the concept, and some of the controllability were proposed; The theory and practice of traditional Chinese medicines should be combined in order to effectively integrate and apply various modern scientific and technical methods, and create new ideas about toxicity studies of CMM, which has the important significance on the comprehensive understanding about CMM toxicity, strengthening the research on CMM toxicity, and promoting the safety of CMM in clinical use.
ABSTRACT
According to the basic theories of process engineering and their developing histories, considering the development of pharmaceutical industry of Chinese materia medica (CMM), the process engineering features in all sectors of the CMM whole production process were discussed on the point of systematical engineering, and a wider concept of CMM process engineering was suggested. Its research contents were analyzed and lastest achievements were reviewed in this paper.
ABSTRACT
The screening with quality control of solubilizing excipient is one of the reasons that restrict the development of Chinese materia medica (CMM) injection. In order to establish an screening and quality evaluation system for solubilizing excipient so as to ensure the safety and utility of CMM injection in clinic, the author introduced a new method which meets with the characteristics of CMM injection, for evaluating the quality of solubilizing excipient. This original method consists of the sequential analysis of "routine examination-physical property-chemical analysis-biological detection", laying particular emphasis on the biological detection. This research is expecting to provide ideas and technical reference for the safety evaluation of CMM injection.
ABSTRACT
Given in-depth study on the numerous chemical constituents from commonly used Chinese materia medica (CMM) whose pharmacodynamic material basis have not been completely clear yet, the tested virtual screening method has been used to reveal the pharmacodynamic material basis. It would be an unimaginable thing to experimentally evaluate the activity of every compound on all interrelated biomacromolecule targets one by one. In this study, the attempt of applying high-throughput virtual screening method to discover the therapeutically effective components, which represented corresponding active components in the given CMM, was developed. For the Chinese herb Sang (Morus alba) including Mori Folium, Mori Fructus, Mori Ramulus, and Mori Cortex, a molecular library consisted of their 510 known chemical components was docked with four target models related to antidiabetic and diuretic activity using Molegro software, respectively. It was shown that the numbers of components with theoretical activity on α-glucosidase and carbonic anhydrase XII were far more than those on insulin receptor and mineralocorticoid receptor, and some components were observed to display potent theoretical activity on multiple targets. Besides, the forecast of activity of some components aiming at α-glucosidase was found to be supported by literature experimental data. On the basis of these results, we deduced that the antidiabetic and diuretic activity of Sang could be mainly due to the effects on α-glucosidase and carbonic anhydrase XII, rather than those on insulin receptor and mineralocorticoid receptor. Virtual screening method should help us to build a new open mind for clarifying CMM pharmacodynamic material basis.
ABSTRACT
Chinese materia medica (CMM) as well as its interrelated industries has huge exploitable potential and developing prospect At present, it has become one of the directions with the worldwide exploitation of new medicine and development in medicinal industry The establishment of quality standard system of CMM in China is one of the key problems that the modernization of them should be first of all resolved In order to ensure the accuracy, credibility, comparability and mutual recognition of data examined by each laboratory, our research should be based on the international theory and method of the traceability Our government and CMM administration department should strengthen the esablishment and promulgation of criteria, laws, regulations of CMM and its interrelated industries, so as to make the quality assurance system approach to the international standard, and to protect our economic benefits, people's health and most consumers' interests from being affected
ABSTRACT
Chinese materia medica (CMM) has double complexity in bioactive ingredient and its mechanism. It is difficult to explain by the modern biomedicine theory So it seriously restricts the modernization of CMM The modern CMM should have the high quality standard to meet the needs of international standard It can be guaranteed by spreading the GAP for Chinese medicinal materials and GMP for standard production The mechanism depends on using the DNA microarray to set up “the gene expression difference chart”, to study on the combination of CMM and gene expression difference chart Meanwhile, we can establish a totally new method of screening modern CMM based on the gene expression difference chart, it can really make the modernization and internationalization of CMM
ABSTRACT
Chinese materia medica(CMM) industry is one of the most national identity in China′s industries.According to the development situation in recent years,putting forward some reasonable ideas will promote better and faster development of the CMM industry.In this paper,through the literature review combined with CMM industry development status,the current structure of CMM industry was analyzed.And based on the concept of the industrial chain,the CMM industry chain structure was analyzed and described.The proposal of building a harmonious CMM industry chain was put forward clearly,which will conform to the requirements of the CMM industry development.Above all,this article has provided some constructive ideas for future development of CMM industry.
ABSTRACT
To propose a new pattern for quality control and evaluation of Chinese materia medica(CMM).The limitation of quality control pattern for CMM was investigated and a new method for quality evaluation has been explored and designed,combining with the introduction on the conception of matter-element evaluation model and its application to product quality evaluation in value engineering,as well as the research survey on the spectrum-activity relationship of CMM.The new method for quality evaluation referred to the results of research concerning the spectrum-activity relationship of CMM.Taking the quality grade,quality index,and chemical composition of CMM as matter-elements,the evaluated grades and tested data were normalized to establish the matter-element model.With the establishment of the improved quality control method,which is in accordance with the basic characteristics of CMM,it is expected that the safety,efficiency,and quality stability of CMM could be ensured and a new scientific research strategy and technological support could be provided to promote the modernization of CMM.
ABSTRACT
Chinese materia medica (CMM) defines health as the balance of whole body system and medications are designed to restore this balance. Unlike western medicine that generally uses a single chemical entity and sets a single physiological target, the efficacy herbal formulations in CMM results from complex mixtures of numerous chemical components which simultaneously interact with multiple molecular targets. CMM clinically shows the advantages over western medicine in the treatment of some multi-gene and multifactor diseases, yet the adoption of CMM stemmed from natural animals and plants in modern society is impeded by lack of quality control and absence of scientific proof of their effectiveness. Currently, the development of combinatorial medicines and system biology provide new opportunities to modernize the CMM. Thus, this review focuses on the modernization of CMM by employing the concept of combination therapy and cutting-edge biomedical technologies such as proteomics, biochip, and chemical biology. Moreover, the author puts forward the new ideas and methodologies for the discovery of modern multicomponent drugs from CMM.